About C. diff.

What is a C. diff. infection (CDI)?

Clostridioides difficile infection (CDI), also known as C. diff., is an infection that happens when Clostridioides difficile (C. difficile) bacteria grow and produce toxins in your intestines. Toxins made by C. difficile cause inflammation, leading to symptoms like diarrhea, abdominal pain, loss of appetite, fever, nausea, and vomiting.

What causes CDI?

CDI often forms after people have used antibiotics. Antibiotics treat infections by destroying bad bacteria in the intestines, but they also destroy good bacteria. Without enough good bacteria to help keep a healthy balance, C. difficile can grow out of control and cause infection.

Aren’t there already drugs for CDI?

There are already approved drugs for CDI, but the infection can sometimes come back. The study drug in the Ri-CoDIFy 3 study is designed to reduce the chances that CDI will come back. It does this by targeting the C. difficile bacteria and leaving other bacteria alone so that a healthy balance of bacteria remains in the body.